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2024's Top 10 Methyl Folate

Find out what to look for in a quality Methyl Folate and what to watch out for

What is Methyl Folate?

Methyl folate, also known as L-methyfolate or 5-MTHF (L-methylfolate calcium), is a type of B vitamin that plays a crucial role in many bodily functions. This essential nutrient is responsible for DNA synthesis, cell division, and metabolism, which are all critical processes in maintaining a healthy body. In this blog post, we will explore the benefits of methyl folate for your health, the importance of getting enough of this vitamin, and how you can ensure you are getting enough in your diet.

Benefits of Methyl Folate

1. Methyl folate and Mental Health
Adequate levels of methyl folate are crucial for maintaining good mental health. Low levels of this vitamin have been linked to depression, anxiety, and other mood disorders. In fact, research has shown that supplementing with methyl folate may improve symptoms of and prevent mood disorders. This is because methyl folate helps regulate the production of neurotransmitters, such as serotonin and dopamine, which play a role in mood regulation.

2. Methyl Folate and Cardiovascular Health
Methyl folate also plays an important role in cardiovascular health. This nutrient works to reduce levels of homocysteine in the blood, a compound that can damage the lining of blood vessels and lead to heart disease. High levels of homocysteine have been linked to an increased risk of heart disease, stroke, and other cardiovascular conditions. By reducing homocysteine levels, methyl folate helps protect against these conditions.

3. Methyl Folate and Pregnancy
Pregnant women require adequate levels of methyl folate for the healthy development of the fetus. This is because methyl folate is necessary for neural tube development, which forms the spinal cord and brain. Low levels of this vitamin during pregnancy have been linked to an increased risk of birth defects, such as spina bifida. For this reason, pregnant women are often advised to supplement with methyl folate to ensure they have enough of this essential nutrient.

4. Methyl Folate and Digestive Health
Methyl folate plays a role in digestive health as well. This vitamin is essential for the production of digestive enzymes and is needed for the breakdown and absorption of nutrients in the digestive tract. Low levels of methyl folate have been linked to digestive issues such as irritable bowel syndrome, inflammatory bowel disease, and other gastrointestinal disorders.

Potential Side Effects

1. Digestive Issues
One of the most common side effects associated with methyl folate supplementation is digestive issues. These can include symptoms like nausea, vomiting, bloating, and diarrhea. These symptoms may be mild or severe, and can occur with short-term or long-term use of the supplement. If you experience digestive issues while taking methyl folate, speak to your healthcare provider to determine the best course of action.

2. Allergic Reactions
Some people may experience an allergic reaction to methyl folate, particularly if they have an allergy to other B-vitamins or folate. Symptoms can include swelling of the face, lips, tongue, or throat, rash or hives, and difficulty breathing. An allergic reaction to methyl folate can be life-threatening. If you experience any of these symptoms after taking methyl folate, seek medical attention immediately.

3. Headaches
Headaches are another potential side effect associated with methyl folate supplementation. These can range from mild to severe, and may occur sporadically or on a regular basis. If you experience headaches while taking methyl folate, speak to your healthcare provider to determine the cause and the best course of action.

2024's Top 10 Methyl Folate

1. Quality 

All the products we recommend have been third party tested to ensure they meet our high standards of quality.

2. Cost 

Getting your hands on a high quality supplement doesn’t have to break the bank. While our top priority will always be quality, we understand that price factors into many people’s buying decisions.

3. Brand Reputation

To ensure that your buying experience is a pleasant one, we recommend only products from companies with strong reputations for providing quality customer service and prompt shipping.

OVERALL RATING

99%

Nutricost L-Methylfolate is the #1 Rated Methyl Folate, as it is high quality and half the price of its competitors. Nutricost L-Methylfolate is a formula that offers 1,000mg of Methyl Folate in each serving. Click Here for Lowest Price

Uniquely, Nutricost is one of the few companies that control the full chain of manufacturing, from sourcing to manufacturing in an FDA-registered facility to warehousing and fulfillment, ensuring strict quality standards are met. Nutricost also offers exceptional customer support for all of its products.

Priced under $13, Nutricost L-Methylfolate comes with 120 servings, which is just $.11 per serving. With Nutricost, you can be assured that this product does NOT contain ANY extra ingredients, fillers, or preservatives.

Nutricost Methyl Folate comes with a 120-day, no-questions-asked, money-back guarantee – the best guarantee on the market!

  • 120 Capsules Methyl Folate (120 Servings)
  • 1,000mcg Methyl Folate Per Serving
  • Vegetarian Capsules
  • Non-GMO & Gluten Free & 3rd Party Tested
  • Made in a GMP Compliant, FDA Registered Facility

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

95%

Amazon Price: $8.99

  • Cardiovascular and Neurologic Health support supplement: Contains one 60 count bottle of Jarrow Formulas Extra Strength Methyl Folate 400 mcg Veggie Capsules for a 60-day supply.
  • Dietary supplement with 400 mcg of Methyl Folate (5-MTHF), a biologically active form of Vitamin B9 to support cardiovascular health, proper cell division and neurologic health.*
  • Features Quatrefolic methyl folate that can cross the blood-brain barrier.*
  • Suggested Use: Adults, take one capsule once a day with or without food, or as directed by your qualified healthcare professional.
  • *These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

92%

Amazon Price: $11.25

  • Get a brain boost – Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognition—especially as you age.
  • Pump up the heart health – This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
  • Metabolically active form – 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folate’s 5-MTHF form.
  • Ingredients matter – We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
  • Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

90%

Amazon Price: $23.00

  • Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
  • Positivity: Supports a healthy outlook*
  • Nerves & Circulation: Supports healthy blood vessel and nerve function*
  • Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

88%

Amazon Price: $13.46

  • CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
  • METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

86%

Amazon Price: $22.99

  • ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
  • ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
  • ♥ Suitable for people who are diagnosed with MTHFR mutation
  • ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA.

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

83%

Amazon Price: $21.95

  • Special Features – Top grade methyl folate (5-MTHF) contained in vegetarian capsules, 15mg per serving, biologically active form of folic acid, efficiently absorbed vitamin B9 benefits.
  • Benefits & Use – Taking methyl folate on a regular basis may effectively replenish low B vitamin levels for men and women, you may notice support for prenatal development, brain function, energy production, and overall cellular strength.
  • Dosage & Servings – 240 vegetable capsules per bottle, 2 veg capsule serving size, provides 15mg pure L-Methylfolate from 25,000mcg dietary folate equivalent per dose, lasts up to a 4-month supply (120 servings).
  • Purpose – L-methylfolate or 5-MTHF, is the biologically active form of the B vitamin folate, it doesn't require conversion by the body and is readily available for absorption and use.
  • Quality Ensured – Non-GMO ingredients that are 3rd party lab tested and passed. Made without gluten, dairy, eggs, peanuts, soy, wheat, yeast, & tree nuts.

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

80%

Amazon Price: $24.99

  • Essential B Vitamin: Folate is a water-soluble essential B vitamin which helps maintain homocysteine levels already within normal range
  • MORE PREFERABLE THAN SYNTHETIC FOLIC ACID - Our Body has limited capacity to transform folic acid into folate, Supplementation with methyl folate is highly preferable for the production and maintenance of new cells.
  • Non-GMO & Gluten Free
  • Free of sugar, starch, soy, yeast, corn, wheat, egg, artificial color, flavor, & preservatives.
  • Made with strict GMP Standards

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

77%

Amazon Price: $21.99

  • PROFESSIONAL STRENGTH: Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of Folate.
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.
  • BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
  • CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

OVERALL RATING

75%

Amazon Price: $22.80

  • Contains 5-MTHF: Metafolin is directly usable by the body and has been shown to be the only form of folate to cross the blood-brain barrier.*
  • Essential B Vitamin: Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits, and beans essential for a variety of processes in the body.*
  • Vitamins/Minerals/Amino Acids: supplement formulated to provide beneficial support in filling important nutrient gaps.*
  • Our uncompromising operational practices at our state-of-the-art manufacturing facilities surpass GMP standards and manufacturing regulations. All of our products are GMO-free.
  • For 65 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals. As a globally recognized leader in the development of innovative, science-based nutritional supplements, we strive to help healthcare professionals and their patients push their potential for healthy living, today and in the future.*

*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

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