2021's 10 Best Betaine HCl + Pepsin
TOP SUPPLEMENTS

Best Betaine HCl + Pepsin

Betaine HCl is a natural amino acid supplement consisting of betaine and hydrochloric acid. Betaine, otherwise known as trimethylglycine, is an amino acid derivative that was originally found in beets and was first discovered in the 19th century. (See Reference 5)

Hydrochloric acid (HCl) is a strong acid naturally produced in the stomach along with sodium chloride (NaCl) and potassium chloride (KCl). The resulting digestive fluid (gastric acid) (See Reference 2) plays a vital role in both digestion (by breaking down the food we eat) and immunity (by fighting bacteria and pathogens that enter the stomach).

There has been growing research in recent years that suggest that betaine HCl has a few potentially life-changing benefits. Here’s what the research says.

Benefits of Betaine HCl + Pepsin

Digestive Health

The most common use of betaine HCI supplementation is to treat digestion issues that arise from a lack of acid production in the stomach, also known as hypochlorhydria. Insufficient stomach acid leads to a rise in the pH level of the stomach, which lead to issues mentioned above, such as indigestion, heartburn, and nutritional deficiencies. (See Reference 1)

Multiple studies have found betaine to noticeably improve the digestive process in humans. For example, a 2014 study examined the effect of 1500mg of betaine HCI given orally while monitoring pH continuously for two hours. Participants were pharmacologically induced with hypochlorhydria, bringing their pH levels to above 4. Once a pH of over 4 was sustained for 15 minutes, the betaine HCI was given. They found betaine HCI to significantly lower gastric by a staggering 4.5 from a pH of 5.2 to 0.6. The effects were quick, with a sub-3 pH being achieved in 6.3 minutes.

Once a normal pH range in the region of 1.5 – 3 is obtained, stomach acid is now in a position to perform the following functions.

  • No Heartburn: The body now shuts the lower esophageal sphincter due to increased stomach acid levels which in turn prevents acid splashing up into the esophagus and causing heartburn.
  • Proper Digestion: At this pH level, a powerful digestive enzyme called protease is activated, which breaks down proteins into amino acids.
  • Kills Bacteria: Unwanted bacterial pathogens in the food we eat are killed off due to the low pH conditions in the stomach.

IMPORTANT NOTE: The same symptoms presented by low levels of stomach acid are also associated with high levels of stomach acid. With two vastly different medical cases presenting similar symptoms, it is vital that you get an official diagnosis from your doctor before taking any supplements.

Heart Health

High levels of homocysteine in the bloodstream can lead to the buildup of plaque in the arteries, also known as atherosclerosis. (See Reference 3) This condition is one of the leading causes of heart issues. But how does betaine HCI fit into this? Well, a 2013 study found betaine supplementation to be an effective agent in decreasing blood homocysteine in healthy individuals. This drop in homocysteine levels reduces the blocking and hardening of arteries. (See Reference 4)

Possible Side Effects

Overdosing can damage the lining of the stomach, which presents itself with a burning sensation. If you experience this stop taking it immediately.

Do not take betaine HCl if:

  • You are on anti-inflammatory medication such as aspirin or ibuprofen because they can damage the GI lining that could then be aggravated by HCl supplementation
  • Your betaine HCl supplement does not contain pepsin. Without pepsin, the body cannot properly break down proteins into peptides for absorption
  • You are currently pregnant or breastfeeding

2021's 10 Best Betaine HCl + Pepsin
TOP SUPPLEMENTS

Our list of the top 10 Betaine HCl supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All ten of these top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high quality supplement. In addition, all the companies represented on our top ten list have stellar records with customer service and prompt shipping to ensure that your supplement experience is enjoyable from the first click to your final dose.

Nutricost Betaine HCl + Pepsin is the #1 Rated Betaine HCl Supplement, as it is high quality and half the price of its competitors. Nutricost Betaine HCl + Pepsin features 650mg of betaine HCl and 140mg of Pepsin in each capsule. Click Here for Lowest Price

Uniquely, Nutricost is one of the few companies that control the full chain of manufacturing, from sourcing to manufacturing in an FDA-registered facility to warehousing and fulfillment, ensuring strict quality standards are met. Nutricost also offers exceptional customer support for all of its products.

Priced under $13, Nutricost Betaine HCl + Pepsin comes with 240 capsules, which is just $0.05 per capsule. With Nutricost, you can be assured that this product does NOT contain ANY extra ingredients, fillers, or preservatives.

Nutricost Betaine HCl + Pepsin comes with a 120-day, no-questions-asked, money-back guarantee – the best guarantee on the market!

  • Our #1 betaine HCl supplement
  • Amazon's Choice for Betaine HCl Pepsin
  • Only a Nickel per serving
  • 650mg of betaine HCl and 140mg of Pepsin in each capsule
  • Non-GMO, gluten-free, and made in the USA!
  • No artificial colors, flavors, or chemical preservatives
  • 120-day, no-questions-asked, money-back guarantee!
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • DIGESTIVE FUNCTION: Betaine HCL and pepsin are gastric-juice components essential to the digestion of food and absorption of most nutrients.*
  • NUTRIENT ABSORPTION: Betain HCL is necessary for adequate absorption of protein, calcium, vitamin B12, and iron.*
  • GUT HEALTH: Betaine HCL contributes to the naturally acidic environment of the stomach necessary for healthy microbial balance.*
  • PURE INGREDIENTS: Pure Encapsulations manufactures a line of hypoallergenic, research-based dietary supplements. Products are meticulously formulated using pure ingredients designed to deliver predictable results for the benefit of all patients, even the most sensitive.*
  • FREE FROM: Pure Encapsulations products are free from wheat, gluten, egg, peanuts, magnesium stearate, hydrogenated fat, artificial sweeteners and colors, and other unnecessary excipients. Any product containing ingredients derived from allergens, such as soy, dairy or shellfish is clearly labeled. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • SUPPORTS HEALTHY DIGESTION: Do you ever feel like no matter what you eat your stomach has trouble breaking down your food? HCL or Hydrochloride provides your stomach with the support it needs to break down food properly, leaving you feeling refreshed.
  • SUPPORTS THE PRODUCTION OF STOMACH ACID: In order to properly digest food, and avoid feelings of bloating and indigestion, you need the proper of amount of HCL or Hydrochloride in your stomach. HCl- Plus contains nutrients to help support the formation of stomach acid.
  • ENJOY AND UTILIZE YOUR FOOD: Do you get stomach aches after we eat. For many, supplementing specific digestive nutrients may be beneficial. For those, HCl-Plus supplies targeted digestive support to ensure proper digestive function, allowing you to enjoy and utilize the food you eat.
  • WHO WE ARE: We are Biotics Research. We have revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. We drive advancement by focusing our initiatives on research, natural effectiveness, product safety, efficacy, unparalleled quality control and continuing innovation.
  • QUALITY MADE IN THE USA: We produce tablets, capsules, powders and liquids in our Rosenberg, Texas, FDA-Registered, Texas Department of Health licensed, GMP-certified production and laboratory facility. Our products are tested in our state of the art laboratory to ensure their safety, efficacy, and purity, and HCl-Plus, like all Biotics Research products, is Gluten Free!
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • Betaine HCI/pepsin/gentian bitters contains three nutritional factors that perform complementary functions designed to support the efficiency of the digestive process and supplementing with betaine hci may support the stomach's digestive capacity
  • Pepsin is an enzyme produced by the body to digest protein-containing foods in the stomach and works in conjunction with stomach acid to support protein digestion.
  • Gentian is an herb used to optimize the digestive capacity and tonify the digestive tract. Its bitter nature may help to stimulate the body's production of digestive enzymes.
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • High Potency: Provides 650 mg Betaine HCL and 162 mg Pepsin for healthy digestive support
  • Digestion Booster: May help support healthy hydrochloric stomach acid levels that decrease with age
  • Gut Healthy: A key stomach enzyme, Pepsin may help support digestive function & gut health
  • Trusted Brand: Manufactured in our own facility & lab verified for purity, potency & identity
  • Customers Say: “Easy to swallow & my stomach is much happier now. Favorite brand of HCL!”
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • A potent digestive aid*
  • Promotes protein and fat digestion*
  • Supports optimal stomach acidity*
  • Free from manufacturing agents, coatings, colorings, binders, fillers and release agents
  • No Magnesium Stearate, Silica, Dioxides, Sulfates, Starch, Soy, Nuts, or Milk
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • Used as a supplemental source of hydrochloric acid
  • Can be utilized by the stomach to produce pepsin
  • The combination of betaine hydrochloride and pepsin provide an excellent stomach tonic
  • Pepsin breaks down proteins into smaller, more easily absorbed substances
  • 1 tablet with a meal, up to four times daily
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • Adequate amounts of hydrochloric acid are necessary for the absorption of vitamins and minerals, and to maintain a sterile environment in the stomach.
  • Pepsins represent approximately 70% of the protein-digesting enzymes needed to convert the protein in food into usable amino acids.
  • Easy-to-swallow vegetarian capsules
  • This product contains no sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • INDIGESTION: Benefits individuals with occasional indigestion*
  • PROTEIN DIGESTION: Promotes optimal stomach acidity and protein digestion*
  • LACTOSE-FREE: Pepsin ingredient is undiluted and lactose-free
  • TWO SIZES: Available in bottles of 225 and 450 capsules
  • FREE FROM: Every Thorne product is made with the purest possible ingredients – without gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no dairy, soy, yeast, fish, or shellfish.
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.

  • REQUIRED FOR THE PROPER ABSORPTION OF NUTRIENTS - Betaine HCl is an excellent source of hydrochloric acid, which is produced by the parietal cells of the stomach. Hydrochloric acid is required for the proper absorption of nutrients, including vitamin B12 and minerals such as calcium, magnesium, zinc, iron, and selenium. *
  • SUPPORT DIGESTIVE FUNCTION - Betaine HCl provides 750 mg betaine hydrochloride along with pepsin, a key protein digestive enzyme produced in the stomach. This product is ideal for those who are looking to support their stomachs digestive function. Taking one capsule before a meal aids digestion, especially the digestion of protein-containing foods, and supports the assimilation of nutrients. *
  • UPGRADED DELIVERY - This product was previously in a tablet form. However, we have upgraded to a capsule. This change ensures delivery of betaine HCl and pepsin to the stomach where they are needed to initiate digestion. *
  • HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Non-GMO and Gluten-Free.
  • OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.
  • #1 IN CONSUMER SATISFACTION - Designs for Health was voted #1 in Consumer Satisfaction in 2016 and 2017 in a Consumer Labs survey of Healthcare Practitioner Brands.
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*Individual Results May Vary - Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product's website for more information.